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Irbesartan & Hydrochlorothiazide tablet are useful for the treatment of hypertension. This tablet might be Employed in patients whose blood pressure is just not sufficiently controlled on monotherapy. This tablet may also be employed as Preliminary therapy in people who're very likely to want multiple prescription drugs to obtain their blood pressure level targets.
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Irbesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to your AT1 angiotensin II receptor. There is also an AT2 receptor in several tissues, but It isn't linked to cardiovascular homeostasis.
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Irbesartan won't inhibit ACE or renin or have an affect on other hormone receptors or ion channels recognised for being involved with the cardiovascular regulation of blood pressure and sodium homeostasis.
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